Description
Product details
Pipracan Injection contains a combination of Piperacillin and Tazobactam, a broad-spectrum injectable antibacterial therapy used for the treatment of moderate to severe bacterial infections caused by susceptible organisms. Piperacillin is an extended-spectrum penicillin antibiotic that works by inhibiting bacterial cell-wall synthesis. Tazobactam is a beta-lactamase inhibitor that protects piperacillin from degradation by certain beta-lactamase enzymes, thereby extending its antibacterial activity against susceptible beta-lactamase-producing bacteria. Pipracan Injection 2.25 g & Pipracan Injection 4.5 g Generic Name: Piperacillin + Tazobactam Dosage Form: Injection Available Strengths Product Piperacillin Tazobactam Total Strength Pipracan 2.25 g Injection 2 g 0.25 g 2.25 g Pipracan 4.5 g Injection 4 g 0.5 g 4.5 g Therapeutic Uses Depending on approved labeling and susceptibility of the causative organism, Piperacillin/Tazobactam may be used for serious bacterial infections such as: Complicated intra-abdominal infections Pneumonia and selected lower respiratory tract infections Complicated urinary tract infections Skin and soft-tissue infections Certain gynecological infections Other severe susceptible bacterial infections The exact indications vary according to local approved product information. Dosage & Administration The dosage and duration of Pipracan Injection depend on: Type and severity of infection Susceptibility of the causative organism Patient's age and body weight Kidney function Clinical response Site of infection Piperacillin/Tazobactam is administered intravenously after appropriate reconstitution/dilution. Dose adjustment is generally required in patients with significant renal impairment. Preparation, compatible diluents, infusion duration, and stability should follow the manufacturer's product instructions. Precautions Check for previous allergy to penicillins, cephalosporins, or other beta-lactam antibiotics. Assess kidney function before and during treatment when clinically appropriate. Dose adjustment may be necessary in renal impairment. Monitor blood counts during prolonged treatment. Electrolytes may require monitoring because piperacillin formulations can contribute a sodium load. Severe or persistent diarrhea should be evaluated for Clostridioides difficile-associated diarrhea. Prolonged treatment may result in overgrowth of non-susceptible organisms. Review concurrent medicines for clinically significant interactions. Pregnancy and breastfeeding require appropriate medical assessment. Side Effects Possible adverse effects include: Diarrhea Nausea Vomiting Headache Rash Injection-site reactions Important adverse reactions can include: Severe hypersensitivity or anaphylaxis Severe skin reactions Kidney dysfunction Blood-cell abnormalities Electrolyte disturbances Antibiotic-associated colitis Warning Pipracan Injection is a prescription antibiotic intended for administration under qualified medical supervision. Piperacillin/Tazobactam should be used for confirmed or strongly suspected susceptible bacterial infections. Inappropriate antibiotic use can contribute to antimicrobial resistance. FAQ 1. What does Pipracan Injection contain? It contains Piperacillin and Tazobactam, an antibiotic plus beta-lactamase inhibitor combination. 2. What does Pipracan 2.25 g contain? The standard 2.25 g combination contains Piperacillin 2 g + Tazobactam 0.25 g. 3. What does Pipracan 4.5 g contain? The standard 4.5 g combination contains Piperacillin 4 g + Tazobactam 0.5 g. 4. How does Piperacillin work? Piperacillin interferes with bacterial cell-wall synthesis, leading to bacterial cell death in susceptible organisms. 5. What is the role of Tazobactam? Tazobactam inhibits certain beta-lactamase enzymes that could otherwise inactivate piperacillin. 6. Does Piperacillin/Tazobactam cover Pseudomonas? It has activity against susceptible strains of Pseudomonas aeruginosa, but actual susceptibility should be determined according to microbiological testing and local resistance patterns. 7. Does kidney disease affect the dosage? Yes. Piperacillin and tazobactam are substantially eliminated through the kidneys, so dose adjustment may be necessary in renal impairment. 8. Can Pipracan treat viral infections? No. Piperacillin/Tazobactam is an antibacterial medicine and does not treat viral infections such as influenza or the common cold. 9. Can Pipracan cause allergic reactions? Yes. Serious hypersensitivity reactions can occur, particularly in patients with a history of allergy to penicillins or other beta-lactam antibiotics. 10. How is Pipracan Injection administered? It is administered intravenously after appropriate preparation, according to the prescribed regimen and manufacturer's instructions
